HPV L1 Antibodies for Neutralization and Vaccine Development

Human papillomavirus (HPV) is a virus from the papillomavirus family that is capable of infecting humans. Like all papillomaviruses, HPVs establish productive infections only in keratinocytes of the skin or mucous membranes. There are nearly 200 different strains of HPV, most of which are harmless and not cancer causing. Out of all these 14 high-risk HPV types (HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68) are known to lead to cancers of the cervix, vulva, vagina, penis, oropharynx and anus, and another 6 are suspected of causing cancer. In addition, HPV has been linked with an increased risk of cardiovascular disease.