Integrated, Not Isolated Data Collection The biggest challenge with RPM data is usually where it lives. With Locus, data doesn't sit in a separate portal: Direct to EHR: We feed "discrete data" directly into your EMR flowsheets from our ecosystem of both Bluetooth and Cellular connected devices which include common vital signs, as well as spirometry, fetal doppler, and growing. Manage by Exception: Our system filters the "noise." Instead of scrolling through thousands of normal readings, your team is alerted only when a patient’s data trends outside of their personal "normal" range. This is further fine-tuned by health system partners. Outcomes: Our data consistently demonstrates how remote monitoring has lowered readmission rates and/or shortened hospital stays.

Locus offers several methods for health systems to access and analyze their data: Reporting Dashboard: A built-in dashboard within the Locus web application that provides immediate visibility into program metrics. Custom SQL Reports: The platform supports the creation of specialized

Locus Health’s bidirectional communication capabilities are managed via feature flags, allowing health systems to customize the level of patient engagement based on specific program needs or clinical capacity. Feature Flag Customization Administrators can choose to enable or disable the following communication channels: In-App Messaging: This optional feature allows for secure, non-urgent messaging between the care team and the patient. Video Visits: Programs have the option to "Turn On" video capabilities for 1-to-1 visits or group sessions with up to 49 participants, such as centering sessions or group counseling. Notifications: Clinicians can enable or disable real-time notifications via email or SMS for measurement alerts and new messages. If these are disabled, alerts will still display within the web portal for the care team to manage. Patient notifications happen via HIPAA-compliant banner notifications and "nudges" to take vital signs or login to see a message.

Accessibility and WCAG Compliance Locus is committed to an "accessibility-first" design philosophy, adhering to international standards to ensure an inclusive digital experience: WCAG Compliant Design: The application is built following Web Content Accessibility Guidelines (WCAG), which focus on making digital content perceivable, operable, understandable, and robust for individuals with various disabilities. Native Accessibility Tool Support: The app is designed to work seamlessly with iOS and Android native mobile tools. This allows patients to utilize standard features such as: Screen Readers (e.g., VoiceOver on iOS and TalkBack on Android) for patients with visual impairments. Text Resizing and high-contrast modes to improve readability. Voice Control and other assistive technologies provided by mobile operating systems. Equitability and Localization To ensure health equity, Locus addresses linguistic and social barriers through targeted features: Language Localization: The Locus patient app is fully localized in English and Spanish, allowing a broader demographic to engage with their care plans in their preferred language. Flexible Access Options: Recognizing that not all patients have the same resources, Locus offers four ways to access the platform: BYOD (Bring Your Own Device): Use the app on a personal iPhone or Android device. Cellular-Enabled iPads: Locus can provide pre-configured, cellular-ready tablets for patients who do not have reliable internet or their own mobile devices. Web-Based Portal (PWA): A web-accessible version for use on any browser. Simple Connectivity: Features like cellular hub connectivity and automated data transmission help patients in rural or underserved areas stay connected without needing complex technical setups.

Pediatric Care Pathways Locus is a leader in pediatric remote patient monitoring (RPM), serving many of the top children's hospitals in the United States. Their pediatric pathways focus on "feeders and growers" and medically complex patients to reduce length of stay (LOS) and improve outcomes. Cardiac: High-risk cardiology, heart failure, VAD, TRAC, and exercise programs for older CHD patients. NICU: Complex discharges (NG tubes/Oxygen), feeders and growers, and substance-exposed newborns. Pulmonary: Asthma, Cystic Fibrosis, and Trach/Vent care. General/Other: Solid organ transplant, palliative care, outpatient antimicrobial therapy (OPAT), and the transition from TPN to oral feeds. Adult Care Pathways For adult populations, Locus provides pathways aimed at managing chronic conditions and reducing 30-day readmission risks. Oncology: Specifically developed through NIH/National Cancer Institute awards, including chemotherapy treatment and medication monitoring. Cardiac: Heart failure and cardiac rehab. Pulmonary: COPD and pneumonia. Surgical: Bariatric and urology pathways. General/Chronic: Endocrinology, high-risk obstetrics, mental health, weight management, and spinal cord injury. Transplant: Solid organ and stem cell transplant. Pathway Customization and Scalability While these pathways are prebuilt based on clinical evidence and established best practices, they remain highly flexible: Configurability: Care teams can choose from over 70 different measurement types to design a dashboard that fits their specific program needs. Enterprise Integration: Pathways are integrated directly into the EMR (e.g., Epic, Cerner), allowing for discrete data return and SSO access for clinicians. Logistics Support: Locus manages the full logistics of these pathways, including shipping branded kits with integrated devices (scales, BP monitors, etc.) directly to patients' homes.

The Locus platform is designed to be fully integrated into enterprise health systems. Key features include: Discrete Data Integration: Biometric and symptomatic data from remote monitoring is sent back to the EMR as discrete data, making it actionable within the patient's record. Single Sign-On (SSO): Clinicians can access the Locus dashboard directly through the EMR using SSO via SMART on FHiR, reducing the need for multiple logins. EMR-Based Enrollment: Programs can be configured to allow patient enrollment directly via an EHR order, as seen in implementations like the Inova health system. Patient Portal Integration: Patients can have the option to launch the Locus application directly from within their MyChart (Epic) portal. Appointment Synchronization: Locus can integrate with health system scheduling to provide appointment reminders and updates within the remote monitoring app. This includes incorporating schedules from an EMR, infusion, and transplant systems into one centralized reminder.

Locus Health provides a structured support model designed to ensure clinical continuity while maintaining efficient operational assistance for both providers and patients: 24/7/365 Urgent Support: Locus offers around-the-clock support every day of the year specifically for urgent care-blocking issues. This ensures that critical clinical workflows and monitoring remain functional at all times. Core Office Hours: Standard support services are available Monday through Friday, from 8:30 a.m. EST to 8:30 p.m. EST, excluding federal holidays. Logistics and Shipping Support: During office hours, the Locus team manages the logistics of picking, packing, and shipping branded kits directly to clinics or patient homes. Help Desk and Technical Assistance: The Locus Help Desk is available during office hours to assist with account activation and device connectivity support. Clinical and Patient Engagement: Support staff work during office hours to encourage patient engagement and provide necessary training for clinicians to ensure they are proficient with the platform.

Locus Health provides a highly configurable framework for health systems to deliver patient education and health coaching materials directly within the Locus app. To ensure a personalized and flexible patient journey, systems can utilize the following content delivery methods: Automated Delivery Logic: Content can be scheduled for auto-delivery based on specific milestones, such as how long a patient has been enrolled in a program. Manual Triggering for Individual Needs: Clinicians have the ability to manually trigger specific content to patients at any time. This ensures that educational resources and coaching tools are tailored to meet unique, patient-centered care requirements as they arise. Hosted Educational Content: Health systems can host a variety of multimedia resources, including PDFs and Videos, to provide clinical guidance and self-care instructions. Surveys and PROMs: Clinicians can integrate questionnaires and Patient Reported Outcome Measures (PROMs) to gather qualitative data and assess patient progress.

While Locus is primarily an enterprise remote patient monitoring solution, its flexible communication infrastructure enables specialized partnerships—such as with the Ollie Hinkle Heart Foundation—and supports remote cardiac rehab programs for both 12-week and 24-week sessions. These programs leverage Locus's bidirectional communication tools to achieve the following: 1-to-1 and Group Support Sessions: The platform can "turn on" video visit capabilities to host private consultations or group centering sessions for up to 49 participants. Structured Coaching Delivery: Health systems can host and auto-deliver educational PDFs, videos, and surveys tailored to the specific timeline of a 12 or 24-week cardiac recovery journey. Patient-Centered Adjustments: Clinicians can manually trigger specific coaching content or questionnaires based on a patient's individual progress or behavioral health requirements during rehab.

Locus has demonstrated its impact in oncology through the following partnerships and clinical studies: COVID-19 Oncology Management: Locus support enables managing oncology patients at home during treatment, a practice highlighted for its efficiency and safety during the COVID-19 pandemic. Inova Schar Cancer Institute Pilot: An NCI-funded pilot to remotely monitor gastrointestinal cancer patients with connected devices, symptomatic questions, combined infusion and EMR scheduling integration, complimented by HCO authored "What to Expect" video series. Wearable Oncology Trial: Locus participated in a prospective clinical trial titled "A Pilot Prospective Clinical Trial Using Remote Monitoring for Cancer Patients Undergoing Outpatient Chemotherapy" led by Dr. John Deeken. Study Focus: The trial utilized Apple Watch data (steps, sleep, activity) and symptomatic questions for patients starting cycle one, day one of chemotherapy and infusion. Awards: The Inova Schar Cancer Center received an Innovation Award in July 2021 from the Association of Cancer Care Centers for its work with Locus. NCI Grants and Research As an NIH/National Cancer Institute (NCI) SBIR Awardee (2021-2024) with a Phase 1 and Phase 2 award, Locus developed a compliment of advanced care oncology navigation features to work alongside their connected device, bidirectional communication, and EMR integration features